Just back from the Silk Road to Samarkand and thought I would share some tips.
Flights - very little legroom on Friday flight out; consider extra legroom/exit row seats if tall. Tuesday flight back had a lot more legroom. Plane toilets were disgusting, avoid towards the end of the flight unless recently freshened! Food good. Pillows and blankets get reused so not very hygienic.
Money - local guide acted as money changer for Uzbek Sum. In most places you can now pay in Dollars and sometimes Euros for souvenirs so change small amounts to Sum for drinks, photo permits etc. as you go.
Toilets - be prepared for a lot of the squat variety and bush stops on long bus days. Useful for ladies to wear a skirt on the long driving days. Wipes and hand gel invaluable!
Mosquitoes - didn't see a single mosquito, wear repellent or use a plug in the whole trip. Take a small repellent just in case.
Health - take Immodium or equivalent with you. After Day 7 most people had a slightly dodgy tummy!
Water - a bottle of water was provided every day for drinking and teeth cleaning.
Clothing - climate is quite variable. Layers useful first thing in the morning and on the way back from dinner when it can be chilly.
Itinerary - don't expect to follow the Day to Day itinerary. The guides rearrange according to time, weather, other groups to get the best out of the trip and give you some free time. It is full on so don't expect much downtime.
Khiva - if time on arrival, explore while it's quiet and most of the tourists have gone. Inner city very compact so hard to get lost.
Bukhara - take the optional lunch at a local house if offered. It was a chance to see how Plov is made and sample some. It was help yourself so worth the experience even if not that hungry.
Shakhrisabz - currently a building site with little sign of greenery considering it means "Green City". The taxi ride through the mountains to get there is interesting and a good experience. Once there the monuments are not as spectacular as elsewhere although the souvenir prices are very cheap. If not your cup of tea, opt for a further free day in Samarkand.
This trip gives you a fascinating insight into Central Asia. A thoroughly enjoyable and unforgettable experience.