Hello Susie
I went on this holiday in September last year and rate it up there as one of the best holidays I have been on with JY (17 in all).
If you have been on any of the long haul holidays you will know they can be quite full on at times and this holiday is no different from any of the others. The Uzbeks are lovely people and I felt safer there than just about any country I have been to and would have no hesitation in going back, I would love to do that some day. You will probably have to go "al fresco" on some of the loo stops but I don't think many people on my trip found that a problem, think most of us found it a bit of a laugh, you'll be able to find your own little "niche", and nobody bothers about what others are doing anyway. I would suggest it may be better to wear a skirt on long journey days.
Think of it as an adventure rather than a challenge, just take all the usual precautions you would when holidaying and I'm sure you will have a great time, I'm quite envious.
Happy holiday
Avocet