Hi Toni, I think I also answered a post of yours on another thread - I've had numerous vaccinations over the last few years for various long haul tours - hepatitis, typhoid, tetanus etc. The only new ones I needed for this tour were three rabies jabs, just as a precaution. They do not prevent you getting rabies, but in the very unlikely event of you being bitten by a bat or a monkey, it gives you around 72 hours to get to a clinic/hospital!
Regarding money, if the tour doesn't include lunch and dinner, I usually budget around $50 a day and take a couple of hundred US$ extra just in case and I usually come home with some cash as well. If you let your bank know before you go, you should be able to use you debit card in ATMs as well and let your credit card company know as well, then you can use it too. Better safe than sorry! As far as I remember most (but not all) of the hotels had room safes.
All the best,
Bob